研究成果

塚原が2009年4月に赴任して以降、研究室が発表した主な論文

• Abe N, Sakiyama A, SuzukiM , Win-Shwe TT, Suzuki T, Kawashima T, Tsukahara S: Ethynylestradiol feminizes gene expression partly in testis developing as ovotestis and disrupts asymmetric müllerian duct development by eliminating asymmetric gene expression in Japanese quail embryos. Toxicological Sciences, 199, 210-226, 2024.
• Win-Shwe TT, Abe N, Sakiyama A, Suzuki M, Sano K, Kawashima T, Tsukahara S: In ovo o,p’-DDT exposure induces malformation of reproductive organs and alters the expression of genes controlling sexual differentiation in Japanese quail embryo. Journal of Applyed Toxicology, 44, 699-711, 2024.

• Morishita M, Kobayashi K, Mitsuzuka M, Takagi R, Ono K, Momma R, Tsuneoka Y, Horio S, Tsukahara S: Two-step actions of testicular androgens in the organization of a male-specific neural pathway from the medial preoptic area to the ventral tegmental area for modulating sexually motivated behavior. Journal of Neuroscience, 43, 7322-7336, 2023.

• Tsukahara S, Morishita M, Sasaki S, Wakayama K, Kobayashi K, Ohno K, Kawashima T: Sexually dimorphic expression of sexual differentiation genes in the internal genital organs of Japanese quail embryos. General and Comparative Endocrinology, 113917, doi: 10.1016/j.ygcen.2021.113917, 2021.
• Morishita M, Kamada A, Tsukahara S: Neuronal activation of the sexually dimorphic nucleus of the preoptic area in female and male rats during copulation and its sex differences, Neuroscience Letters, 755, 135915. doi: 10.1016/j.neulet.2021.135915, 2021.
• Tsukahara S, Morishita M: Sexually dimorphic formation of the preoptic area and the bed nucleus of the stria terminalis by neuroestrogens. Frontiers in Neuroscience, 14, 797, doi: 10.3389/fnins.2020.00797, 2020.
• Ogawa S, Tsukahara S, Choleris E, Vasudevan N: Estrogenic regulation of social behavior and sexually dimorphic brain formation. Neuroscience and Biobehavioral Reviews,110, 46-59, 2020.
• Okino E, Morita S, Hoshikawa Y, Tsukahara S: The glutamatergic system in the preoptic area is involved in the retention of maternal behavior in maternally experienced female rats. Psychoneuroendocrinology, 120, 104792. doi: 10.1016/j.psyneuen.2020.104792, 2020.
• Morishita M, Koiso R, Tsukahara S: Actions of peripubertal gonadal steroids in the formation of sexually dimorphic brain regions in mice. Endocrinology, 161, 6, 1-17, 2020.
• Nakashima S, Morisita M, Ueno K, Tsukahara S: Region-specific effects of copulation on dendritic spine morphology and gene expression related to spinogenesis in the medial preoptic nucleus of male rats. Psychoneuroendocrinology, 108, 1-13, 2019.
• Maejima S, Abe Y, Yamaguchi S, Musatov S, Ogawa S, Kondo Y, Tsukahara S: VGF in the medial preoptic nucleus increases sexual activity following sexual arousal induction in male rats. Endocrinology, 159, 12, 3993-4005, 2018.
• Yamaguchi S, Abe Y, Maejima S, Tsukahara S: Sexual experience reduces neuronal activity in the central part of the medial preoptic nucleus in male rats during sexual behavior. Neuroscience Letters, 685, 155-159, 2018.
• Kanaya M, Morishita M, Tsukahara S: Temporal expression patterns of genes related to sex steroid action in sexually dimorphic nuclei during puberty. Frontiers in Endocrinology, 9, 213, doi: 10.3389/fendo.2018.00213, 2018.
• Matsuda KI, Uchiyama K, Mori H, Maejima S, Yamaguchi S, Tanaka M, Tsukahara S: Sexual behavior-associated c-Fos indcuation in the sagittalis nucleus of the hypothalamus in male rat. Neuroscience Letters, 661, 104-107 2017.
• Morishita M, Maejima S, Tsukahara S: Gonadal hormone-dependent sexual differentiation of a female-biased sexually dimorphic cell group in the principal nucleus of the bed nucleus of the stria terminalis in mice. Endocrinology, 158, 10, 3512-3525, 2017.
• Moe Y, Kyi-Tha-Thu C, Tanaka T, Ito H, Yahashi S, Matsuda KI, Kawata M, Katsuura G, Iwashige F, Sakata I, Akune A, Inui A, Sakai T, Ogawa S, Tsukahara S: A sexually dimorphic area of the dorsal hypothalamus in mice and common marmosets. Endocrinology, 157, 12, 4817-4828, 2016.
• Moe Y, Tanaka T, Morishita M, Ohata R, Nakahara C, Kawashima T, Maekawa F, Sakata I, Sakai T, Tsukahara S: A comparative study of sex difference in calbindin neurons among mice, musk shrews, and Japanese quails. Neuroscience Letters, 631, 63-69, 2016.
• Htike NT, Maekawa F, Soutome H, Sano K, Maejima S, Kyaw Htet Aung, Tokuda M, Tsukahara S: Arsenic exposure induces unscheduled mitotic S phase entry coupled with cell death in mouse cortical astrocytes. Frontiers in Neuroscience, 10, 297, doi: 10.3389/fnins.2016.00297, 2016.
• Maejima S, Ohishi N, Yamaguchi S, Tsukahara S: A neural connection between the central part of the medial preoptic nucleus and the bed nucleus of the stria terminalis to regulate sexual behavior in male rats. Neuroscience Letters, 606, 66-71, 2015.
• Kyi Tha Thu C, Okoshi K, Ito H, Matsuda KI, Kawata M, Tsukahara S: Sex differences in cells expressing green fluorescent protein under the control of the estrogen receptor-α promoter in the hypothalamus of mice. Neuroscience Research, 101, 44-52, 2015.
• Tsukahara S, Kanaya M, Yamanouchi K: Neuroanatomy and sex differences of the lordosis-inhibiting system in the lateral septum. Frontiers in Neuroscience, 8, 299, doi: 10.3389/fnins.2014.00299, 2014.
• Kanaya M, Tsuda CM, Sagoshi S, Nagata K, Morimoto C, Chaw Kyi Tha Thu, Toda K, Kato S, Ogawa S, Tsukahara S: Regional difference in sex steroid action on formation of morphological sex differences in the anteroventral periventricular nucleus and principal nucleus of the bed nucleus of the stria terminalis. PLoS One, 9, 11, e112616, 2014.
• Kyaw Htet Aung, Tin-Tin Win-Shwe, Kanaya M, Takano H, Tsukahara S: Involvement of hemeoxygenase-1 in di(2-ethylhexyl) phthalate (DEHP)-induced apoptosis of Neuro-2a cells. Journal of Toxicological Sciences, 39, 2, 217-229, 2014.
• Kyaw Htet Aung, Kurihara R, Nakashima S, Maekawa F, Nohara K, Kobayashi T, Tsukahara S: Inhibition of neurite outgrowth and alteration of cytoskeletal gene expression by sodium arsenite. Neurotoxicology, 34, 226-235, 2013.
• Kato Y, Nakashima S, Maekawa F, Tsukahara S: Involvement of postnatal apoptosis on sex difference in number of cells generated during late fetal period in the sexually dimorphic nucleus of the preoptic area in rats. Neuroscience Letters, 516, 2, 290-295, 2012.
• Tsukahara S, Tsuda M, Kurihara R, Kato Y, Kuroda Y, Nakata M, Xiao K, Nagata K, Toda K, Ogawa S: Effects of aromatase or estrogen receptor gene deletion on masculinization of the principal nucleus of the bed nucleus of the stria terminalis of mice. Neuroendocrinology, 94, 2, 137-147, 2011.
• Koike-Kuroda Y, Kakeyama M, Fujimaki H, Tsukahara S: Use of live imaging analysis for evaluation of cytotoxic chemicals that induce apoptotic cell death. Toxicology In Vitro, 24, 7, 2012-2020, 2010.